Diane Kuharsky

Diane Kuharsky
Assistant Teaching Professor, Science
Office Phone
Office Location
109 Forker Lab
147 Shenango Avenue
Sharon, PA 16146

    Dr. Kuharsky earned her bachelor’s degree in biology from Slippery Rock University and clinical doctorate from the University of Pittsburgh. Her clinical residency was completed at the Veteran’s Administration Hospital in Pittsburgh. Upon graduation, she was a health care provider at St. John's Specialty Care Center in Mars, Pa., where she worked primarily in the skilled nursing setting. She has a variety of research interests and has participated in numerous research studies involving the areas of physical therapy, biomedical research and biological research. She took her first full-time teaching position at Slippery Rock University, remaining there for three years before joining the Shenango campus full-time. Dr. Kuharsky is an advisor for students in the Physical Therapist Assistant program. She teaches courses for students primarily entering the Physical Therapist Assistant, Occupational Therapist Assistant and Nursing programs as well as specific courses for the PTA and OTA programs. She was the recipient of the Teaching Excellence Award in 2013.

    Outside of the classroom, her interests include skiing, hiking and gardening.

    Research Interests

    Physical Therapy

    Biomedical Research

    Biological Science Research


    Reliability, internal consistency, and validity of data obtained with the functional gait assessment. Wrisley DM, Marchetti GF, Kuharsky DK, Whitney SL. Phys Ther. 2004 Oct;84(10):906-18. PMID: 15449976

    Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia. Yin XM, Luo Y, Cao G, Bai L, Pei W, Kuharsky DK, Chen J. The Journal of biological chemistry. 2002; 277(44):42074-81. PubMed [journal]PMID: 12200426

    Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis.Li S, Zhao Y, He X, Kim TH, Kuharsky DK, Rabinowich H, Chen J, Du C, Yin XM. The Journal of biological chemistry. 2002; 277(30):26912-20. PubMed [journal]PMID: 12011074

    Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury. Zhao Y, Li S, Childs EE, Kuharsky DK, Yin XM. The Journal of biological chemistry. 2001; 276(29):27432-40. PubMed [journal]PMID: 11369777

    Effects of Prolonged Freezing and Supercooling on Body Composition, Pupariation, and Adult Emergence of Eurosta solidaginis (Diptera: Tephritidae). Layne Jr JR, Kuharsky DK Environmental Entomology. 2001; 30:12-16.

    Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax. Kim TH, Zhao Y, Barber MJ, Kuharsky DK, Yin XM. The Journal of biological chemistry. 2000; 275(50):39474-81. PubMed [journal]PMID: 10982793

    Triggering of Cryoprotectant Synthesis in the Woolly Bear Caterpillar (Pyrrharctia isabella Lepidoptera: Arctiidae). Layne Jr JR, Kuharsky DK. Journal of Experimental Zoology. 2000; 286:367-371.


    Doctor of Physical Therapy, University of Pittsburgh

    Bachelor of Arts in Biology, Slippery Rock University of Pennsylvania